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Synthesis and Cytotoxic Potential of 3-Oxo-19-trifluoroacetoxy-18H-oleane-28-oic Acid by Elmira F. Khusnutdinova Alexander I. Poptsov & Oxana B. Kazakova

Author:Elmira F. Khusnutdinova, Alexander I. Poptsov & Oxana B. Kazakova , Date: April 15, 2024 ,Views: 11

Synthesis and Cytotoxic Potential of 3-Oxo-19-trifluoroacetoxy-18H-oleane-28-oic Acid by Elmira F. Khusnutdinova Alexander I. Poptsov & Oxana B. Kazakova

Author:Elmira F. Khusnutdinova, Alexander I. Poptsov & Oxana B. Kazakova
Format: pdf
Tags: Trifluoroacetic acid-promoted Wagner-Meerwein rearrangement of betulonic acid carboxamide led to the formation of the expected 19,28-lactam along with a new germanicane-type 3-oxo-19-trifluoroacetoxy-18H-oleane-28-oic acid. The structure of this triterpenoid was confirmed by 2D NMR analyses. A primary evaluation of biological potency revealed an anticancer activity with GI50 < 5 M against leukemia, colon cancer, breast cancer, and prostate cancer cell lines, while the parent compounds were not active., triterpenoids; lupane; betulin; oleanane; allobetulin; germanicane; Wagner–Meerwein rearrangement; cytotoxic activity; NCI-60


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Synthesis and Cytotoxic Potential of 3-Oxo-19-trifluoroacetoxy-18H-oleane-28-oic Acid by Elmira F. Khusnutdinova Alexander I. Poptsov & Oxana B. Kazakova.pdf


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